{"id":72,"date":"2021-12-14T16:56:26","date_gmt":"2021-12-14T16:56:26","guid":{"rendered":"https:\/\/antibody.work\/?p=72"},"modified":"2021-12-14T17:07:55","modified_gmt":"2021-12-14T17:07:55","slug":"immunity-cover-illustration-for-the-batistalab","status":"publish","type":"post","link":"https:\/\/antibody.work\/?p=72","title":{"rendered":"Immunity Cover Illustration for the @Batistalab"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/twitter.com\/BatistaLab\/status\/1470789089494552586?s=20\n<\/div><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-bottom is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p>antibody.work consulted <a href=\"https:\/\/www.biomedgraphics.com\" data-type=\"URL\" data-id=\"https:\/\/www.biomedgraphics.com\">Biomedgraphics<\/a> for the conceptualization and design an <a href=\"https:\/\/www.cell.com\/immunity\/home\" data-type=\"URL\" data-id=\"https:\/\/www.cell.com\/immunity\/home\">Immunity<\/a> cover illustration that accompanies the wonderful malaria antibody study from <a href=\"https:\/\/ragoninstitute.org\/batista\/\" data-type=\"URL\" data-id=\"https:\/\/ragoninstitute.org\/batista\/\">Barista Laboratory<\/a> at the Ragon Institute. <\/p>\n\n\n\n<p><em>Caption from the cover: Improvement of antibodies targeting the\u00a0Plasmodium falciparumcircumsporozoite protein (PfCSP) could have substantial impact on malaria control. In this issue, Kratochvil et al. (2859\u20132876) engineer a mouse model expressing the inferred germline DNA sequence of a PfCSP-targeting antibody, CIS43, that has prevented malaria in clinical trials and use vaccine immunofocusing and bioinformatic sieving to generate CIS43-variant antibodies. One of these, iGL.CIS43.D3, showed 10-fold improved protective capacity over CIS43 and is the best-in-class malaria-protective antibody identified to date. The mouse model encoding the inferred germline DNA sequence of CIS43 thus \u201cturns back the clock\u201d on the mature antibody (upper left dial) and integrates feedback from somatic hypermutation (upper right dial), structure (lower left dial), and affinity (lower right dial) to guide the <\/em>selection and engineering of antibody variants. Illustration by Christina Corbaci and Lars Hangartner.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>antibody.work consulted Biomedgraphics for the conceptualization and design an Immunity cover illustration that accompanies the wonderful malaria antibody study from Barista Laboratory at the Ragon Institute. Caption from the cover: Improvement of antibodies targeting the\u00a0Plasmodium falciparumcircumsporozoite protein (PfCSP) could have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":78,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-72","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-viz","clearfix"],"jetpack_featured_media_url":"https:\/\/antibody.work\/wp-content\/uploads\/2021\/12\/cover.tif-2.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/antibody.work\/index.php?rest_route=\/wp\/v2\/posts\/72","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/antibody.work\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/antibody.work\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/antibody.work\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/antibody.work\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=72"}],"version-history":[{"count":9,"href":"https:\/\/antibody.work\/index.php?rest_route=\/wp\/v2\/posts\/72\/revisions"}],"predecessor-version":[{"id":83,"href":"https:\/\/antibody.work\/index.php?rest_route=\/wp\/v2\/posts\/72\/revisions\/83"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/antibody.work\/index.php?rest_route=\/wp\/v2\/media\/78"}],"wp:attachment":[{"href":"https:\/\/antibody.work\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=72"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/antibody.work\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=72"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/antibody.work\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=72"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}